Compaction Roller types

December 12, 2020

Cover imageThe influence for the roller compaction process on granule quality of four several types of lactose showing different particle dimensions, volume thickness, crystallinity and morphology was contrasted by modeling. For every types of lactose the influence associated with parameter configurations regarding friability had been modeled by an extra purchase polynomial having different average relative deviation values. Force, roll speed, straight and horizontal screw rate had been important variables for many kinds of lactose but stress was the most important parameter followed by the roll rate plus the horizontal screw speed. Kind, particle size and density had an influence on functional roller compactor parameter settings. The best quality ended up being gotten if at a top force a reduced horizontal screw speed was selected per roll speed. Roller compaction of spray-dried lactose had been tough. A gradual decrease of granule quality was seen for α-lactose monohydrate 200M, anhydrous -lactose, α-lactose monohydrate 90M and spray-dried α-lactose, respectively. The roller compaction procedure using the different types of lactose had been reproducible.


  • Roller compaction;
  • Lactose;
  • Dry granulation;
  • Granule;
  • Friability


  • ARD%, average general deviation (per cent);
  • CV%, coefficient of variation (percent);
  • F, granule friability (per cent);
  • HS, horizontal screw speed (rpm);
  • Pair, atmosphere force (kPa);
  • Poil, hydraulic pressure, oil pressure (MPa);
  • RS, roll rate (rpm);
  • SF, sieve fraction 250–1000 m (%);
  • VS, straight screw rate (rpm)
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